| Bioactivity | PI3Kα-IN-1 is a PI3Kα inhibitor (IC50 < 0.5 nM), and also inhibits mTOR (IC50: 104 nM)[1]. |
| Invitro | PI3Kα-IN-1 在小鼠肝微粒体测定中表现出良好的稳定性 (t1/2 值 > 60 分钟)[1]。PI3Kα-IN-1 (48 h) 在 MDC7 细胞中诱导细胞毒性，IC50 值约为 170 nM[1]。PI3Kα-IN-1 (15-250 nM) 抑制 MCF7 细胞中的磷酸化 4EBP、磷酸化-P70SK6 和磷酸化-473AKT[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PI3Kα-IN-1 相关抗体: |
| CAS | 2100855-80-7 |
| Formula | C26H25N7O3 |
| Molar Mass | 483.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Al-Ashmawy AAK, et al. Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122. |