| Bioactivity | PI3K-IN-41 (compound 2) is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. PI3K-IN-41 has potential to be used in precisely controlled cancer therapeutics. PI3K-IN-41 exhibits potent PI3K ihibition upon UV light irradiation, and enhances antitumor effect[1]. |
| Target | IC50:18.92 nM (PI3K) |
| Invitro | PI3K-IN-41 (copound 2) (10 nM) 它会降低 HGC-27 细胞中的 AKT 磷酸化，并在紫外线照射 5 分钟、15 分钟和 30 分钟后，(1-10 μM) 抑制 HGC-27 细胞的集落形成[1]。 0 --> PI3K-IN-41 相关抗体: |
| Name | PI3K-IN-41 |
| Formula | C45H39F2N5O12S |
| Molar Mass | 911.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tian H, et al. Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release. ACS Med Chem Lett. 2023 Jul 24;14(8):1100-1107. |