| Bioactivity | PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM)[1]. |
| Invitro | PI3K-IN-37 (0.005-10 μM; 30 min) treatment inhibits PKB Ser473 phosphorylation in Rat1 cells[1].PI3K-IN-37 (0.005-1 μM; 60 min) treatment inhibits S6 Ribosomal Protein phosphorylation Ser235/236 in TSC1 nult MEF cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | PI3K-IN-37 |
| CAS | 1257547-40-2 |
| Formula | C25H26N6O2 |
| Molar Mass | 442.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. FURET Pascal, et al. 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES. WO2010139731A1. |