| Bioactivity | PI3K-IN-35 (Compound 6l) is a highly selective PI3K inhibitor with IC50 values of 13.98, 7.22 and 10.94 μM for PI3K-α、PI3K-β and PI3K-δ, respectively. PI3K-IN-35 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-35 can be used in leukemia research[1]. |
| Invitro | PI3K-IN-35 (Compound 6l) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1].PI3K-IN-35 (Compound 6l) induces cell cycle arrest toward the G2-M phase (41.61%) and leads to DNA synthesis and apoptosis[1].PI3K-IN-35 (Compound 6l) (10 μM, 48 hours) results in apoptotic with 16.98% of cells in the early and latest age[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | PI3K-IN-35 |
| CAS | 2458163-99-8 |
| Formula | C25H23N7O2 |
| Molar Mass | 453.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |