| Bioactivity | PI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research[1]. |
| Invitro | PI3K-IN-34 (Compound 6g) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1].PI3K-IN-34 (Compound 6g) induces cell cycle arrest toward the G2-M phase (45.75%) and leads to DNA synthesis and apoptosis[1].PI3K-IN-34 (Compound 6g) (10 μM, 48 hours) results in apoptotic with 22.83% of cells in the early and latest age[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | PI3K-IN-34 |
| CAS | 2458163-94-3 |
| Formula | C23H22N6O3 |
| Molar Mass | 430.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |