| Bioactivity | PI3K-IN-33 (Compound 6e) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-33 can be used in leukemia research[1]. |
| Invitro | PI3K-IN-33 (Compound 6e) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1].PI3K-IN-33 (Compound 6e) induces cell cycle arrest toward the G2-M phase (30.3%) and leads to DNA synthesis and apoptosis[1].PI3K-IN-33 (Compound 6e) (10 μM, 48 hours) results in apoptotic with 12.13% of cells in the early and latest age[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | PI3K-IN-33 |
| CAS | 2458163-92-1 |
| Formula | C23H21BrN6O2 |
| Molar Mass | 493.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051. |
PI3K-IN-33
CAS: 2458163-92-1 F: C23H21BrN6O2 W: 493.36
PI3K-IN-33 (Compound 6e) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α
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