| Bioactivity | PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells[1]. |
| Target | IC50: 0.29 μM (PHGDH). |
| Invitro | PHGDH-IN-5 (Compound B12) 能抑制 MDA-MB-468、NCI-H1975、HT1080 和 PC9 细胞的增殖， IC50 值在 9.93 μM至21.2 μM 之间[1]。PHGDH-IN-5 (10-30 μM) 在 MDA-MB-468 细胞中降低了由 13C6-葡萄糖产生的 M+3-丝氨酸的生成量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PHGDH-IN-5 相关抗体: |
| CAS | 17402-86-7 |
| Formula | C8H5NO4S |
| Molar Mass | 211.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cao XY, et al. Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors. Bioorg Chem. 2024;146:107330. |