| Bioactivity | PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1]. |
| Invitro | Aggregated tau-PHF6 (VQIVYK) potentiates NLRP3 inflammasome expression and autophagy in human microglial cells[1]. |
| Name | PHF6 |
| CAS | 329897-62-3 |
| Sequence | Val-Gln-Ile-Val-Tyr-Lys |
| Shortening | VQIVYK |
| Formula | C36H60N8O9 |
| Molar Mass | 748.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chinmaya Panda, et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cell. 2021 Jun 30;10(7):1652. |