| Bioactivity | PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator[1]. |
| Invitro | PHCCC(4Me) (THCCC; Compound 3) shows micromolar affinityfor mGluR2, with a Ki value of 0.6 μM[1]. |
| Name | PHCCC(4Me) |
| CAS | 1259532-01-8 |
| Formula | C18H16N2O3 |
| Molar Mass | 308.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Stephan Schann, et al. Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators. J Med Chem. 2010 Dec 23;53(24):8775-9. |
PHCCC(4Me)
CAS: 1259532-01-8 F: C18H16N2O3 W: 308.33
PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of
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