| Bioactivity | PHA-543613 hydrochloride is an oral or active α7 nAChR agonist with brain permeability, For α3β4, α1β1γδ, α4β2 and 5-HT3 receptors selective. PHA-543613 hydrochloride affects sensory gating and memory in an in vivo model of schizophrenia[1][1]. |
| Name | PHA-543613 hydrochloride |
| CAS | 1586767-92-1 |
| Formula | C15H18ClN3O2 |
| Molar Mass | 307.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Faghih R, et al. Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. J Med Chem. 2008 Feb 28;51(4):701-12. [2]. Wishka DG, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49(14):4425-36. |
PHA-543613 hydrochloride
CAS: 1586767-92-1 F: C15H18ClN3O2 W: 307.78
PHA-543613 hydrochloride is an oral or active α7 nAChR agonist with brain permeability, For α3β4, α1β1γδ, α4β2
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