| Bioactivity | PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC50=68 μM), and a close structural analog of OSMI-1 (HY-119738)[1]. |
| Invitro | PG34 (0.5-50 µM; 24 h) shows no detectable inhibition of OGT in CHO cells, displays no effect on apoptotic signaling, and shows a moderate effect on cell viability only at the highest concentration[1]. Cell Viability Assay[1] Cell Line: |
| Name | PG 34 |
| CAS | 1681056-62-1 |
| Formula | C28H25N3O5S2 |
| Molar Mass | 547.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rodrigo F Ortiz-Meoz, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. |