| Bioactivity | PFM046 is the antagonist for liver X receptor (LXR), that inhibits the activation of LXRα and LXRβ with IC50 of 2.04 μM and 1.58 μM. PFM046 inhibits the expression of SCD1 and FASN, upregulates the expression of ABCA1, and exhibits antitumor efficacy in mouse models[1]. |
| Target | IC50: 2.04 μM (LXRα); 1.58 μM (>LXRβ) |
| CAS | 3053859-57-4 |
| Formula | C29H42O2 |
| Molar Mass | 422.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pontini L, et al., Discovery of 22(S)-23-phenyl-24-norchol-5-en-3β,22-diol (PFM046) as the first-in-class, steroidal, non-sulfated Liver X Receptor antagonist with anticancer activity. Eur J Med Chem. 2025 Feb 5;283:117136. |