| Bioactivity | PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ)[1]. |
| Invitro | PFM03 (50-400 μM; 30 min) specifically inhibits MRE11 endonuclease activity[1].PFM03 (100 μM; 30 min) causes normal DSB repair in G2 (CENPF+) cells[1].PFM03 (50 μM; 8 h) enhances NHEJ usage but reduces homologous recombination (HR) in cells[1]. |
| Name | PFM03 |
| CAS | 1558598-48-3 |
| Formula | C14H15NO2S2 |
| Molar Mass | 293.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shibata A, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18. |