| Bioactivity | PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). | ||||||||||||
| Invitro | PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | PFI-90 | ||||||||||||
| CAS | 53995-62-3 | ||||||||||||
| Formula | C11H10N4O | ||||||||||||
| Molar Mass | 214.22 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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