| Bioactivity | PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a Ki of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC50 of 568 nM in HTRF assay[1]. |
| Target | EC50: 568 nM (human D1 cAMP)Ki: 113 nM (human D1 receptor) |
| Invitro | Dopamine acts upon neurons through two families of dopamine receptors, D1-like receptors (D1Rs) and D2-like receptors (D2Rs). The D1-like receptor family consists of D1 and D5 receptors which are expressed in many regions of the brain. Dopamine D1 receptors are implicated in numerous neuropharmacological and neurobiological functions[1]. |
| Name | PF2562 |
| CAS | 1609258-91-4 |
| Formula | C19H17N5O |
| Molar Mass | 331.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jennifer Elizabeth Davoren, et al. Heteroaromatic compounds and their use as dopamine d1 ligands. US20140128374A1. |