| Bioactivity | PF-3837 is an Mps1 kinase inhibitor with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. PF-3837 interferes with the cell cycle checkpoint by inhibiting Mps1 catalytic activity, reducing genomic stability, thereby inducing cancer cell apoptosis (Apoptosis). PF-3837 can be used in research on breast cancer[1]. |
| CAS | 2772910-13-9 |
| Formula | C21H26N8O2 |
| Molar Mass | 422.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Martinez R, et al. Mitotic checkpoint kinase Mps1 has a role in normal physiology which impacts clinical utility[J]. PloS one, 2015, 10(9): e0138616. |