| Bioactivity | PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research[1][2][3]. | ||||||||||||
| Invitro | PF 1022A binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF 1022A binds to GABA receptors, which might contribute to the anthelmintic effect[1].In vitro, PF 1022A shows low activity on embryonation but significantly inhibits egg hatch (10 and 100 μg/mL), whereas albendazole (10 and 100 μg/mL) reveales statistically significant inhibitions of both embryonation and egg hatch. PF 1022A (1-100 μg/mL) completely inhibits larval movement at most examination points[3]. | ||||||||||||
| Name | PF 1022A | ||||||||||||
| CAS | 133413-70-4 | ||||||||||||
| Formula | C52H76N4O12 | ||||||||||||
| Molar Mass | 949.18 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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PF 1022A
CAS: 133413-70-4 F: C52H76N4O12 W: 949.18
PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus My
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