| Bioactivity | PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK), with IC50s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively. PF-06835919 can be used for the study of metabolic disorders driven by the overconsumption of Fructose (HY-N0395)[1][2]. | |||||||||
| Target | IC50: 8.4 nM (KHK-C), 66 nM (KHK-A) | |||||||||
| CAS | 2102501-84-6 | |||||||||
| Formula | C16H19F3N4O2 | |||||||||
| Molar Mass | 356.34 | |||||||||
| Appearance | 固体 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS. US 20170183328 A1 [2]. Kentaro Futatsugi, et al. Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose. J Med Chem. 2020 Nov 25;63(22):13546-13560. |
PF-06835919
CAS: 2102501-84-6 F: C16H19F3N4O2 W: 356.34
PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK), with IC50s of 8.4 nM and 66 nM for KHK
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