| Bioactivity | PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion[1]. |
| Name | PF-06827443 |
| CAS | 2115022-67-6 |
| Formula | C24H24N2O4 |
| Molar Mass | 404.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jennifer E Davoren, et, al. Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity. J Med Chem. 2017, 60, 15. |
PF-06827443
CAS: 2115022-67-6 F: C24H24N2O4 W: 404.46
PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulato
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