| Bioactivity | PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity[1]. | ||||||||||||
| Target | IC50: 4.1 nM (RORC2) | ||||||||||||
| Invitro | PF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM[1]. | ||||||||||||
| In Vivo | PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice[1]. Animal Model: | ||||||||||||
| Name | PF-06747711 | ||||||||||||
| CAS | 1892576-58-7 | ||||||||||||
| Formula | C26H26F3N5O2 | ||||||||||||
| Molar Mass | 497.51 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Schnute ME, et al. Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agoni |
PF-06747711
CAS: 1892576-58-7 F: C26H26F3N5O2 W: 497.51
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as ROR
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