| Bioactivity | PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research[1]. | ||||||||||||
| Name | PF-06685249 | ||||||||||||
| CAS | 1467059-70-6 | ||||||||||||
| Formula | C17H16ClN3O3 | ||||||||||||
| Molar Mass | 345.78 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. David J Edmonds, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383. |
PF-06685249
CAS: 1467059-70-6 F: C17H16ClN3O3 W: 345.78
PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK
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