| Bioactivity | PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 trihydrochloride can be used for parkinson's disease (PD) research[1]. | ||||||||||||
| Name | PF-06456384 trihydrochloride | ||||||||||||
| CAS | 1834610-75-1 | ||||||||||||
| Formula | C35H35Cl3F3N7O3S2 | ||||||||||||
| Molar Mass | 829.18 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Ja |
PF-06456384 trihydrochloride
CAS: 1834610-75-1 F: C35H35Cl3F3N7O3S2 W: 829.18
PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3
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