| Bioactivity | PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD)[1][2]. |
| Invitro | PF-06455943 (Compound 22) has inhibition activity for LRRK2 with IC50 values of 3 nM (WT), 9 nM (G2019S) and 20 nM (cellular WCA), respectively[1]. |
| Name | PF-06455943 |
| CAS | 1527474-15-2 |
| Formula | C17H14FN5O |
| Molar Mass | 323.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhen Chen, et al. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2022 Oct 18. [2]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. |
PF-06455943
CAS: 1527474-15-2 F: C17H14FN5O W: 323.32
PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radio
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