| Bioactivity | PF-06426779 is a potent and selective inhibitor of interleukin‑1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM[1]. | ||||||||||||
| Invitro | PF-06426779 inhibits IRAK4, with an IC50 of 12.7 nM in the peripheral blood mononuclear cells (PBMCs) assay[1]. | ||||||||||||
| Name | PF-06426779 | ||||||||||||
| CAS | 1817628-40-2 | ||||||||||||
| Formula | C17H18FN3O4 | ||||||||||||
| Molar Mass | 347.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lee KL, et, al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragme |
PF-06426779
CAS: 1817628-40-2 F: C17H18FN3O4 W: 347.34
PF-06426779 is a potent and selective inhibitor of interleukin‑1 receptor associated kinase 4 (IRAK4), with an IC50 of
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