| Bioactivity | PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively[1]. | ||||||||||||
| Invitro | PF-05381941 inhibits LPS-stimulated release of TNF-αfrom human peripheralmononuclear (PMN) cells with an IC50 of 8 nM[1]. | ||||||||||||
| Name | PF-05381941 | ||||||||||||
| CAS | 1474022-02-0 | ||||||||||||
| Formula | C27H26N6O2 | ||||||||||||
| Molar Mass | 466.53 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kilty I, et al. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013;82(5):500-505. |