| Bioactivity | PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain[1]. |
| Target | IC50: 21 nM (human Nav1.7) |
| Invitro | PF-05186462 inhibits human Nav1.7 channels (IC50=21 nM) in HEK293 cells[1].PF-05186462 exhibits a high plasma protein binding rate[1]. |
| Name | PF-05186462 |
| CAS | 1235406-03-7 |
| Formula | C19H10ClF4N5O3S2 |
| Molar Mass | 531.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jones HM, et, al. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels. Clin Pharmacokinet. 2016 Jul;55(7):875-887. |
PF-05186462
CAS: 1235406-03-7 F: C19H10ClF4N5O3S2 W: 531.89
PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM.
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.