| Bioactivity | PF-05150122 is a novel potent and selective human Nav1.7 channel blocker with the activity of inhibiting human pain signaling. PF-05150122 exhibited favorable biopharmacokinetic parameters in microdose studies, providing a basis for exploring its application in acute or chronic pain inhibition. The pharmacokinetic model of PF-05150122 predicted that at the corresponding oral dose, it could effectively reduce the 50% inhibitory concentration (IC50) of Nav1.7, demonstrating its inhibitory potential[1]. |
| CAS | 1235406-00-4 |
| Formula | C24H21ClN6O3S2 |
| Molar Mass | 541.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels |
PF-05150122
CAS: 1235406-00-4 F: C24H21ClN6O3S2 W: 541.04
PF-05150122 is a novel potent and selective human Nav1.7 channel blocker with the activity of inhibiting human pain sign
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