| Bioactivity | PF-04279405 is a potent and full-acting glucokinase (GK) agonist (EC50=23 nM). Glucokinase (GK) is an enzyme responsible for the conversion of glucose to glucose-6-phosphate and plays a key role in maintaining blood glucose homeostasis. PF-04279405 can be used in the research of type 2 diabetes[1]. |
| CAS | 955881-01-3 |
| Formula | C25H25FN4O4 |
| Molar Mass | 464.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pettersen, et al. The relationship of glucokinase activator–induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies. Toxicologic Pathology 42.4 (2014): 696-708. |
PF-04279405
CAS: 955881-01-3 F: C25H25FN4O4 W: 464.49
PF-04279405 is a potent and full-acting glucokinase (GK) agonist (EC50=23 nM). Glucokinase (GK) is an enzyme responsible
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