| Bioactivity | PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 has the potential for Schizophrenia research[1][2]. | ||||||||||||
| In Vivo | PF-03463275 (1-10 mg/kg; s.c.) attenuates oscillatory potentials (OPs)[2]. Animal Model: | ||||||||||||
| Name | PF-03463275 | ||||||||||||
| CAS | 1173239-39-8 | ||||||||||||
| Formula | C19H22ClFN4O | ||||||||||||
| Molar Mass | 376.86 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19(16):4885. Bronk, Brian S [added]; Schaeffer, Eric [added]]. Bioorg Med Ch [2]. Liu CN, Pettersen B, Seitis G, Osgood S, Somps C. GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats. Cutan Ocul Toxicol. 2014;33(3):206-211. |
PF-03463275
CAS: 1173239-39-8 F: C19H22ClFN4O W: 376.86
PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversi
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