| Bioactivity | PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1]. |
| Invitro | 针对 MMP-12/13 的 PF-00356231 hydrochloride 会因乙酰羟肟酸盐 (AH) 的存在而受到显著影响。在 AH[1]存在的情况下，PF-00356231 hydrochloride 降低 MMP-12 (0.014 μM) 和 MMP-13 (0.27 μM) 的 IC50 值。 0 --> PF-00356231 相关抗体: |
| Name | PF-00356231 |
| CAS | 766536-21-4 |
| Formula | C25H20N2O3S |
| Molar Mass | 428.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76. |
PF-00356231
CAS: 766536-21-4 F: C25H20N2O3S W: 428.50
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteina
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