PF-00277343_product_DataBase

Bioactivity	PF-00277343 is a selective and skin-penetrable THR-β (Ki: 0.51 nM for THR-β, 8.0 nM for THR-α) agonist. PF-00277343 is effective against androgenetic alopecia in animal models[1].
Invitro	PF-00277343 在大鼠肝微粒体中快速代谢 (HLM t1/2 = 40 min)，在大鼠肝细胞中，其半衰期为 45 分钟，清除 CLblood 为 51 mL/min/kg，CLint 为 149 mL/min/kg[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PF-00277343 相关抗体:
In Vivo	PF-00277343 (1 mg/mL 和 0.1 mg/mL，单次局部应用) 可有效诱导 C3H 雌性小鼠的毛发生长[1]。PF-00277343 (静脉注射，0.5 mg/kg) 显示平均全身血浆清除率为 40 mL/min/kg，稳态时的平均表观分布容积为 4.88 mL/min/kg，平均终末期半衰期 2.73 小时[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	332926-04-2
Formula	C24H20FN3O4
Molar Mass	433.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li JJ, et al. Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorg Med Chem Lett. 2010 Jan 1;20(1):306-8.

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