| Bioactivity | PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 of 46 µM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle[1]. |
| Name | PDK4-IN-2 |
| CAS | 1616752-12-5 |
| Formula | C13H10O5 |
| Molar Mass | 246.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kenichi Aizawa, et al. A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction. Cells. 2023 Dec 30;13(1):87. |