| Bioactivity | PDHK-IN-4 (Compound 30) is a potent inhibitor of PDHK with IC50s of 0.0051 and 0.0122 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating drug targets for numerous diseases, including diabetes and cancers. PDHK-IN-4 has the potential for the research of cancer diseases[1]. |
| Name | PDHK-IN-4 |
| Formula | C24H25N5O3 |
| Molar Mass | 431.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bessho Y, et al. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem. 2021 Dec 15;52:116514 |