| Bioactivity | PDEδ autophagic degrader 1 (compound 12c) is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces the PDEδ protein level through lysosome-mediated autophagy without affecting the PDEδ mRNA expression. PDEδ autophagic degrader 1 suppresses the growth in KRAS mutant pancreatic cancer cells[1]. |
| Target | Kd: 56 nM (PDEδ) |
| Name | PDEδ autophagic degrader 1 |
| Formula | C41H42Br2IN7O5 |
| Molar Mass | 999.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jingying Bao, et al. Discovery of Novel PDEδ Autophagic Degraders: A Case Study of Autophagy-Tethering Compound (ATTEC). ACS Med Chem Lett. 2023 Dec 29;15(1):29-35. |
PDEδ autophagic degrader 1
CAS: F: C41H42Br2IN7O5 W: 999.53
PDEδ autophagic degrader 1 (compound 12c) is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces th
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