| Bioactivity | PDE4B/D-IN-4 (compound 4p) is a potent inhibitor of PDE-4B and PDE-4D, with IC50s of 5.50 nM and 6.81 nM, respectively. PDE4B/D-IN-4 shows an increase in the level of intracellular cAMP[1]. |
| Formula | C20H20F2N2O5 |
| Molar Mass | 406.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ahmed M Moussa, et al. Rationale design and synthesis of new roflumilast analogues as preferential selective and potent PDE-4B inhibitors. Bioorg Chem. 2024 Oct 24:153:107911 |