| Bioactivity | PDE4-IN-22 (Compound 2e) is a PDE4 inhibitor with an IC50 value of 2.4 nM. PDE4-IN-22 exhibits anti-inflammatory activity and demonstrates significant anti-psoriatic effects in an Imiquimod (HY-B0180)-induced psoriasis mouse model[1]. |
| Target | IC50: 2.4 nM (PDE4). |
| Formula | C22H19F4N3O3 |
| Molar Mass | 449.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li G, et al. Development of selective heterocyclic PDE4 inhibitors for treatment of psoriasis[J]. European Journal of Medicinal Chemistry, 2024, 280: 116930. |