| Bioactivity | PDE4-IN-13 is a PDE4 inhibitor with an IC50 of 1.56 μM. PDE4-IN-13 shows anti-inflammatory and antioxidant properties， and can be used for chronic obstructive pulmonary disease (COPD) research[1]. |
| Invitro | PDE4-IN-13（化合物 6o）可减少 RAW264.7 巨噬细胞中脂多糖 (LPS) 诱导的 TNF-α 产生以及小鼠肺匀浆中 Fe2+ 诱导的丙二醛 (MDA) 产生。同时，PDE4-IN-13 在还原 Fe3+ 和络合 Fe2+ 方面表现出优异的能力[1]。 0 --> PDE4-IN-13 相关抗体: |
| In Vivo | PDE4-IN-13（化合物 6o）（50 mg/kg 和 100 mg/kg，腹膜内注射）可明显预防 LPS 诱导的小鼠血清 TNF-α 水平[1]。 |
| Name | PDE4-IN-13 |
| Formula | C20H20O5 |
| Molar Mass | 340.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Youzhi Wang, et al. Design and synthesis of a novel class of PDE4 inhibitors with antioxidant properties as bifunctional agents for the potential treatment of COPD. Eur J Med Chem. 2023 Aug 5;256:115374. |