| Bioactivity | PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA. PD-L1/VISTA-IN-1 can block the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity[1]. |
| CAS | 2978623-09-3 |
| Formula | C22H24N4O4 |
| Molar Mass | 408.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sun C, et al. Novel PD-L1/VISTA Dual Inhibitor as Potential Immunotherapy Agents. J Med Chem. 2025 Jan 9;68(1):156-173. |
PD-L1/VISTA-IN-1
CAS: 2978623-09-3 F: C22H24N4O4 W: 408.45
PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA. PD-L1/VISTA-IN-1 can block
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