| Bioactivity | PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1] . | ||||||||||||
| Target | IC50: 23.1 µM (NGF-p75NTR, PC12 cells), 1.8 µM (NGF-p75NTR, PC12nnr5 cells) | ||||||||||||
| Invitro | PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR[1].PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR[1].PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM[1].PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 µM and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively[1]. | ||||||||||||
| Name | PD 90780 | ||||||||||||
| CAS | 77422-99-2 | ||||||||||||
| Formula | C19H14N4O4 | ||||||||||||
| Molar Mass | 362.34 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J |
PD 90780
CAS: 77422-99-2 F: C19H14N4O4 W: 362.34
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with
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