| Bioactivity | PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro[1][2]. | ||||||||||||
| Target | IC50: 9 μM (DDAH1) | ||||||||||||
| Invitro | PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs[1].PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity[1].PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM[2].PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora[2]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | PD 404182 | ||||||||||||
| CAS | 72596-74-8 | ||||||||||||
| Formula | C11H11N3S | ||||||||||||
| Molar Mass | 217.29 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ghebremariam YT, et, al. A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther. 2014 Jan; 348(1): 69-76. [2]. Chamoun-Emanuelli AM, et, al. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob Agents Chemother. 2014; 58(2): 687-97. |