| Bioactivity | PD-168077 is a selective dopamine D4 receptor agonist, with a Ki of 9 nM[1]. |
| Invitro | 在 PD-168077 处理的细胞中，p-CaMKII 在突触部位显著增加了聚集，这通过与 PSD-95 增强的共定位得以指[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PD-168077 相关抗体: |
| In Vivo | PD-168077 (0.2-25.0 mg/kg) 以剂量依赖的方式诱导运动，这种运动形式不寻常且具有特征性的“拖步”，伴随着不协调的动作、打哈欠和阵发性肌阵挛；梳理和抬头行为减少[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 190383-31-4 |
| Formula | C20H22N4O |
| Molar Mass | 334.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Clifford JJ, et al. Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists. Neuropsychopharmacology. 2000 May;22(5):538-44. [2]. Gu Z, et al. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006 Mar;69(3):813-22. |