| Bioactivity | PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1]. |
| Name | PD 145065 |
| CAS | 153049-49-1 |
| Sequence | Ac-{D-Bhg}-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine) |
| Shortening | Ac-{D-Bhg}-LDIIW-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine) |
| Formula | C52H67N7O10 |
| Molar Mass | 950.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. |
PD 145065
CAS: 153049-49-1 F: C52H67N7O10 W: 950.13
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA rec
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