PD-1/PD-L1-IN-54_product_DataBase

Bioactivity	PD-1/PD-L1-IN-54 (Compound 6) is a moderately affinic PD-1/PD-L1 inhibitor (KD: PD-1, 55.8 μM; PD-L1, 46.4 μM; IC50: 88.6 μM). PD-1/PD-L1-IN-54 inhibits PD-1/PD-L1 interactions and shows anticancer activity by activating CD8+ T cells, upregulating PD-1 expression, and increasing secretion of IFN-γ and IL-2. PD-1/PD-L1-IN-54 inhibits cancer cell proliferation and promotes apoptosis. PD-1/PD-L1-IN-54 also regulates T cell immunity through the PI3K/Akt pathway correlated with PD-1/PD-L1[1].
Invitro	PD-1/PD-L1-IN-54 (15-60 μM, 48 h) 可促进 CD8+ T 细胞的增殖并抑制肿瘤细胞 (LLC 和 MC38) 的生长[1]。PD-1/PD-L1-IN-54 (15-60 μM, 48 h) 促进共培养系统中 CD8+ T 细胞分泌免疫细胞因子(IFN-γ 和 IL-2)，并促进肿瘤细胞 (LLC 和 MC38) 的凋亡[1]。PD-1/PD-L1-IN-54 (15-60 μM, 48 h) 促进与 LLC 或 MC38 细胞共培养的 CD8+ T 细胞中 PD-1 表达[1]。PD-1/PD-L1-IN-54 (15-60 μM, 48 h) 调节 PD-1/PD-L1 相互作用的下游通路 (PI3K/Akt)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PD-1/PD-L1-IN-54 相关抗体: Western Blot Analysis[1] Cell Line:
CAS	1393644-68-2
Formula	C17H17ClO7
Molar Mass	368.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kuang QX, et al. New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions. Bioorganic chemistry, 2024, 153, 107899.

PeptideDB

PD-1/PD-L1-IN-54

CAS: 1393644-68-2 F: C17H17ClO7 W: 368.77