| Bioactivity | PD-1/ PD-L1-in-41 (Compound 5c) is a PD-L1 and PD-1 inhibitor with IC50 value of 10.2 nM[1]. |
| Target | IC50: 10.2 nM (PD-1/PD-L1) |
| Invitro | PD-1/PD-L1-IN-41 (Compound 5c) (100 μl; 24小时) 对 CHO-hPD-L1 细胞的 EC50 为 11.6 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PD-1/PD-L1-IN-41 相关抗体: |
| In Vivo | PD-1/PD-L1-IN-41 (Compound 5c) 也可以进行碳-11 的放射性标记，[11C]5c 对 PD-1 阴性和表达 PD-1 的异种移植的 NSG 小鼠都没有特异性结合。这可能归因于放射性示踪剂的快速代谢，血浆蛋白结合引起的组织渗透受限，或非特异性或脱靶相互作用水平升高[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C33H32ClN3O5 |
| Molar Mass | 586.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bamminger K, et al. Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1. J Med Chem. 2024;67(5):4036-4062. |