| Bioactivity | PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability[1]. |
| Target | IC50: 2.4 nM (PD-1/PD-L1) |
| In Vivo | PD-1/PD-L1-IN-32 (compound A56) 在 SD 大鼠中的药代动力学分析[1]Route |
| Name | PD-1/PD-L1-IN-32 |
| CAS | 2765535-21-3 |
| Formula | C29H25ClFN3O3 |
| Molar Mass | 517.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang H, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66(15):10579-10603. |
PD-1/PD-L1-IN-32
CAS: 2765535-21-3 F: C29H25ClFN3O3 W: 517.98
PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-
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