PD-1/PD-L1-IN-14

CAS: 2499965-12-5 F: C24H24N4O2 W: 400.47

PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-

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Bioactivity	PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].
Target	IC50： 27.8 nM (PD-1/PD-L1).
Invitro	PD-1/PD-L1-IN-14 (compound 17) promotes cell-surface PD-L1 internalized into the cytosol and induces the degradation of PD-L1 in tumor cells through a lysosome-dependent pathway[1].
Name	PD-1/PD-L1-IN-14
CAS	2499965-12-5
Formula	C24H24N4O2
Molar Mass	400.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tianyu Wang, et al. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem. 2022 Mar 10;65(5):3879-3893.

4-Acetoxycinnamic acid