| Bioactivity | PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC50 value of 11.9 μM[1]. |
| Target | Proprotein convertase subtilisin-kexin type 9 (PCSK9) |
| Invitro | PCSK9-IN-9 (化合物1) (20 μM; 24 h) 抑制 PCSK9 的 mRNA 水平，而不影响在 HepG2 细胞中的蛋白水平[1]。 |
| Name | PCSK9-IN-9 |
| Formula | C26H36O4 |
| Molar Mass | 412.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pel P, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega, 2022. |