| Bioactivity | PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 TFA selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 TFA increases the autophagic flux of Ub-conjugated aggregates[1]. |
| Invitro | PBA-1105 TFA 在 DC50 为 0.71 nM 和 Dmax,24 hr 为 100 nM 时诱导稳定表达的突变 tau 的自噬降解，随后在更高浓度下产生钩状效应[1]。 PBA-1105（0.1-10 μM；24 小时）TFA 在纳摩尔浓度下诱导错误折叠蛋白质和聚集体的自噬降解。PBA-1105 TFA 导致突变 tau 和错误折叠蛋白质显著降解[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PBA-1105 TFA 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | PBA-1105（20-50 mg/kg；腹膜内注射；每周三次；持续 4 周）TFA 成功减少了转基因小鼠 tauopathies 模型中的 tau 聚集和寡聚物种类[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C41H49F3N2O8 |
| Molar Mass | 754.83 |
| Appearance | 油状物 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13(1):904. |