| Bioactivity | PAT1inh-A0030 is a selective PAT1 (SLC26A6) inhibitor (IC50= 1.0 μM). PAT1inh-A0030 inhibits fluid absorption in the ileum of wild-type and cystic fibrosis (CF) mice (CftrdelF508/delF508) in a closed-loop model of intestinal fluid absorption. PAT1inh-A0030 can be used in the study of intestinal diseases related to CF[1]. |
| Target | PAT1 (SLC26A6). |
| Name | PAT1inh-A0030 |
| CAS | 1030097-65-4 |
| Formula | C17H18N4O3 |
| Molar Mass | 326.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chu T, et al. Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders. RSC Med Chem. 2023 Sep 14;14(11):2342-2347. |
PAT1inh-A0030
CAS: 1030097-65-4 F: C17H18N4O3 W: 326.35
PAT1inh-A0030 is a selective PAT1 (SLC26A6) inhibitor (IC50= 1.0 μM). PAT1inh-A0030 inhibits fluid absorption in the il
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