| Bioactivity | PARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM. PARP1/2-IN-3 inhibits the proliferation of Capan-1 wildtype, AZD2281 or BMN673 resistant cells with IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice[1]. |
| CAS | 3032451-58-1 |
| Formula | C26H21FN6O3 |
| Molar Mass | 484.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang Chun, et al., Phthalazinone or quinazolinone derivatives, pharmaceutical compositions and uses thereof. CN118324766A |